Objective: To identify the frequency and nature of care conflict dilemmas that United States long-term care providers encounter, response strategies, and use of ethics resources to assist with dispute resolution. Design: An online cross-sectional survey was distributed to the Society for Post-Acute and Long-Term Care Medicine (AMDA). Results: Two-thirds of participants, primarily medical directors, have rejected surrogate instructions and 71% have managed family conflict. Conflict over treatment decisions and issues interpreting advance directives were frequently reported. Half of facilities lack a (...) formal dispute mediation policy. Only five respondents have called an ethics consult for assistance. Conclusion: Ethically tense care conflicts commonly arise in long-term and post-acute care facilities. Few facility procedures incorporate ethics resources into actual practice. Recommendations are made to create actionable policy, increase access to ethics services, and support staff skill development in order to improve the end-of-life care experiences for patients, families, and care facility staff. (shrink)

A crisis looms over the scientific enterprise. Not a day passes without news of retractions, failed replications, fraudulent peer reviews, or misinformed science-based policies. The social implications are enormous, yet this crisis has remained largely uncharted-until now. In Science on the Verge, luminaries in the field of post-normal science and scientific governance focus attention on worrying fault-lines in the use of science for policymaking, and the dramatic crisis within science itself. This provocative new volume in The Rightful Place of Science (...) also explores the concepts that need to be unlearned, and the skills that must be relearned and enhanced, if we are to restore the legitimacy and integrity of science. (shrink)

Scandinavia is routinely cited as a global leader in corporate social responsibility and sustainability. In this article, we explore the foundation for this claim while also exploring potential contributing factors. We consider the deep-seated traditions of stakeholder engagement across Scandinavia including the claim that the recent concept of “creating shared value” has Scandinavian origins, institutional and cultural factors that encourage strong CSR and sustainability performances, and the recent phenomenon of movement from implicit to explicit CSR in a Scandinavian context and (...) what this may entail. In sum, we depict the state of the art in CSR and sustainability in Scandinavia. We intend for this to serve as a basis to help establish a globally recognized research paradigm dedicated to considering CSR and sustainability in a Scandinavian context. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

Trenger vi en nanoetikk? Spørsmålet undersøkes ofte gjennom analyser av hva som er spesifikt nytt med nanoteknologi som skulle rettferdiggjøre etableringen av et eget nanoetikkfelt. Artikkelen knytter ikke det nye til teknologiens produkter som sådan, men til det at nanoteknologien oppstår som et nytt og ekspansivt satsningsfelt i en tid med enighet om at etikkrefleksjonen må komme inn på et tidlig tidspunkt. Nanoetikken synliggjør generelle utfordringer for den profesjonaliserte anvendte etikk ettersom nanoetikken etterspørres forut for at feltet kan sies å (...) være etablert. Nanoetikken fordrer en positiv etikk, mens den profesjonaliserte etikk har vært innstilt på en negativ etikk. Utfordringene nanoetikken reiser, er analysert som et problem som har både intellektuell og institusjonell karakter. (shrink)

The American thinker Charles Sanders Peirce, best known as the founder of pragmatism, has been influential not only in the pragmatic tradition but more recently in the philosophy of science and the study of semiotics, or sign theory. Strands of System provides an accessible overview of Peirce's systematic philosophy for those who are beginning to explore his thinking and its import for more recent trends in philosophy.

The study of church growth has historically been divided into two strands of research: the Church Growth Movement and the Social Science approach. This article argues that Dunbar’s Social Brain Hypothesis represents a legitimate and fruitful third strand in the study of church growth, sharing features of both previous strands but identical with neither. We argue that five predictions derived from the Social Brain Hypothesis are accurately borne out in the empirical and practical church growth literature: that larger congregations (...) lead to lower active engagement from members; that single-leader congregations are limited to around 150 members; that congregations of 150 are further stratified into smaller functioning groups; that congregations expanding beyond 150 members undergo internal tensions and are forced to reorganise; and that congregations larger than 150 will require structural sub-divisions to retain active member involvement. While these assertions are reflected in the church growth literature and articulate the common sense assumptions of church growth experts, the Social Brain Hypothesis offers a coherent theoretical framework which unifies these observations and thereby represents a distinctive contribution to church growth studies. (shrink)

_The Sceptics_ is the first comprehensive, up-to-date treatment of Greek scepticism, from the beginnings of epistemology with Xenophanes, to the final full development of Pyrrhonism as presented in the work of Sextus Empiricus. Tracing the evolution of scepticism from 500 B.C to A.D 200, this clear and rigorous analysis presents the arguments of the Greek sceptics in their historical context and provides an in-depth study of the various strands of the sceptical tradition.

I argue that rather than dismiss Foucault’s first book, Mental Illness and Personality, as an “apologetic exposition of Pavlov’s reflexology,” we ought see it as a valuable source documenting Foucault’s change of attitude towards psychology and the history of science in the early 1950s. I argue that there are two distinguishable strands that make up the text. The ‘frame’ of the book—the introduction, first chapter of the second part and conclusion of the book—is expressive of a critical attitude towards psychology, (...) and indicative of rather sophisticated conception of the history of science as a critical history aimed at bringing into view the unscientific forces that shape scientific labor. The ‘main body’ of the text—the first part and the second chapter of the second part—by contrast, reads as the history of the steady dialectical progress of the psychological sciences towards an ever more accurate understanding of mental illness. It is thus indicative to a naïve approach to psychology and to its history. The tension between the two strands of the book thus documents the starting point of Foucault’s then shifting attitudes toward the psychological sciences and the history of science, and the set of questions and sources that lead him to problematize his understanding of and approach to the latter. (shrink)

Essentialism is one of the most pervasive problems in mental health research. Many psychiatrists still hold the view that their nosologies will enable them, sooner or later, to carve nature at its joints and to identify and chart the essence of mental disorders. Moreover, according to recent research in social psychology, some laypeople tend to think along similar essentialist lines. The main aim of this article is to highlight a number of processes that possibly explain the persistent presence and popularity (...) of essentialist conceptions of mental disorders. One such process is the general tendency of laypeople to essentialize conceptual structures, including biological, social, and psychiatric categories. Another process involves the allure of biological psychiatry. Advocating a categorical and biological approach, this strand of psychiatry probably reinforced the already existing lay essentialism about mental disorders. As such, the question regarding why we essentialize mental disorders is a salient example of how cultural trends zero in on natural tendencies, and vice versa, and how both can boost each other. (shrink)

The moral strands of psychology are explored in this collection of essays.

The theme of _Signifying Acts _is that social acts are created by human agents engaging in signifying gestures and elic­iting determined responses—from which flow a number of consequences. This theme is developed by a critical synthesis of various strands of early and contemporary thought in symbolism, meaning, language, and grammar. These strands have been classified as pragma­tism and interactionism, structuralism and grammatical theory Perinbanayagam brings together for the first time the writings of G. H. Mead and his followers, who label (...) their efforts “symbolic interactionism,” and the re­cent developments in the philosophi­cal and anthropological studies of mind and meaning. Through his wide-ranging analysis, he demonstrates the sociologi­cal relevance of Chomsky, Derrida, and Searle and particularizes their contribu­tions to a more comprehensive theoreti­cal framework. The interdisciplinary scope of his thesis recalls Ernest Becker’s _Birth and Death of Meaning, _and his sty­listic flair will stimulate readers at all levels of sophistication. (shrink)

Each volume in the Purdue University Press Series in the History of Philosophy examines the fundamental ideas of a single philosopher, presenting one basic text by the thinker in question, and supplementing this by “a very thorough and up-to-date commentary.” The format is most successful when a reasonably short classic work containing the subject’s most important claims can be found. We might expect it to work much less well with a thinker like Peirce, serious study of whose work cannot avoid (...) taking seriously a large number of different papers and lectures: good reasons can be found for regarding any selection of a basic text unsatisfactory. It is thus a pleasure to report that Douglas Anderson met this challenge with considerable success. The commentary is of very high quality; and his choice of texts, although initially surprising, works very well. (shrink)

Originally published in 1986. Wittgenstein, William James, Thomas Kuhn and John Wisdom share an attitude towards problems in the theory of knowledge which is fundamentally in conflict with the empiricist tradition. They encourage the idea that in understanding the central concepts of epistemology – objectivity, certainty and reasoning – people and their practices matter most. This clash between orthodox empiricism and a freshly inspired pragmatism forms the background to the strands of argument in this book. With these philosophers as a (...) guide, it points to new directions by showing how the theory of knowledge can be shaped around our actions without sacrificing reason’s control over our beliefs. (shrink)

Originally published in 1986. Wittgenstein, William James, Thomas Kuhn and John Wisdom share an attitude towards problems in the theory of knowledge which is fundamentally in conflict with the empiricist tradition. They encourage the idea that in understanding the central concepts of epistemology – objectivity, certainty and reasoning – people and their practices matter most. This clash between orthodox empiricism and a freshly inspired pragmatism forms the background to the strands of argument in this book. With these philosophers as a (...) guide, it points to new directions by showing how the theory of knowledge can be shaped around our actions without sacrificing reason’s control over our beliefs. (shrink)

Originally published in 1986. Wittgenstein, William James, Thomas Kuhn and John Wisdom share an attitude towards problems in the theory of knowledge which is fundamentally in conflict with the empiricist tradition. They encourage the idea that in understanding the central concepts of epistemology – objectivity, certainty and reasoning – people and their practices matter most. This clash between orthodox empiricism and a freshly inspired pragmatism forms the background to the strands of argument in this book. With these philosophers as a (...) guide, it points to new directions by showing how the theory of knowledge can be shaped around our actions without sacrificing reason’s control over our beliefs. (shrink)

This book examines how enlightened Scottish social theorists c.1740 to c.1800 understood the origin and development of religion. Challenging scholarly disregard for the topic, it shows how most prominent thinkers of the Scottish Enlightenment thought deeply about the relationship between religion, human nature and historical change. The Scots viewed this relationship as an important strand within the study of the 'science of human nature' and the 'history of man.' The fruits of this investigation were a sophisticated and innovative account (...) of religious change that is characterized by a striking modernity and naturalism, even by the more devout theorists. The views of the literati surveyed here need to be incorporated into our larger histories of the 'science of religion' as much as they do into our understanding of the social theory of the Scottish Enlightenment. (shrink)

One of the most important and influential philosophers of the last 30 years, John Searle has been concerned throughout his career with a single overarching question: how can we have a unified and theoretically satisfactory account of ourselves and of our relations to other people and to the natural world? In other words, how can we reconcile our common-sense conception of ourselves as conscious, free, mindful, rational agents in a world that we believe comprises brute, unconscious, mindless, meaningless, mute physical (...) particles in fields of force? The essays in this collection are all related to the broad overarching issue that unites the diverse strands of Searle's work. Gathering in an accessible manner essays available only in relatively obscure books and journals, this collection will be of particular value to professionals and upper-level students in philosophy as well as to Searle's more extended audience in such fields as psychology and linguistics. (shrink)

Cohesin establishes sister‐chromatid cohesion during S phase to ensure proper chromosome segregation in mitosis. It also facilitates postreplicative homologous recombination repair of DNA double‐strand breaks by promoting local pairing of damaged and intact sister chromatids. In G2 phase, cohesin that is not bound to chromatin is inactivated, but its reactivation can occur in response to DNA damage. Recent papers by Koshland's and Sjögren's groups describe the critical role of the known cohesin cofactor Eco1 (Ctf7) and ATR checkpoint kinase in (...) damage‐induced reactivation of cohesin, revealing an intricate mechanism that regulates sister‐chromatid pairing to maintain genome integrity.1,2 BioEssays 30:5–9, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

Margolis’ philosophical thought and career is framed by the pragmatism that dominated his early education and his vision of a “resurgent” pragmatism as the most promising direction for an increasingly eclectic Western philosophical tradition. This version of pragmatism is based on Peirce’s formulation of the pragmatic maxim, but Margolis sees the implications of that maxim as running counter to a central strand of Peirce’s own thought: fallibilism as an infinitist, self-correcting process of inquiry asymptotically tending toward to truth and (...) reality. Margolis argues that this version of fallibilism is untenable and un-pragmatic, and his most mature work on the subject identifies an “abductive turn” in Peirce’s philosophy which points in the direction of an improved pragmatism, a pragmatism that is anarchic, relativistic, cast in terms of tolerances instead of laws, and without “Hope” in Peirce’s sense. (shrink)

Mandevillian intelligence is a specific form of collective intelligence in which individual cognitive vices are seen to play a positive functional role in yielding collective forms of cognitive success. The present paper introduces the concept of mandevillian intelligence and reviews a number of strands of empirical research that help to shed light on the phenomenon. The paper also attempts to highlight the value of the concept of mandevillian intelligence from a philosophical, scientific and engineering perspective. Inasmuch as we accept the (...) notion of mandevillian intelligence, then it seems that the cognitive and epistemic value of a specific social or technological intervention will vary according to whether our attention is focused at the individual or collective level of analysis. This has a number of important implications for how we think about the design and evaluation of collective cognitive systems. For example, the notion of mandevillian intelligence forces us to take seriously the idea that the exploitation of individual cognitive shortcomings could, in some situations, provide a productive route to collective forms of cognitive and epistemic success. (shrink)

John R. Searle has made profoundly influential contributions to three areas of philosophy: philosophy of mind, philosophy of language, and philosophy of society. This volume gathers together in accessible form a selection of his essays in these areas. They range widely across social ontology, where Searle presents concise and informative statements of positions developed in more detail elsewhere; artificial intelligence and cognitive science, where Searle assesses the current state of the debate and develops his most recent thoughts; and philosophy of (...) language, where Searle connects ideas from various strands of his work in order to develop original answers to fundamental questions. There are also explorations of the limitations of phenomenological inquiry, the mind-body problem, and the nature and future of philosophy. This rich collection from one of America's leading contemporary philosophers will be valuable for all who are interested in these central philosophical questions. (shrink)

The piRNA class of small RNAs are distinct from other small RNAs by their ∼26–31 nucleotide size, single‐strandedness and strand‐specificity as well as by the clustered arrangement of their origins. Here, we highlight how these features are reminiscent of the mechanisms of DNA replication, and then present three models suggesting that the origin of piRNAs may be mechanistically similar to key processes in DNA replication. BioEssays 29:382–385, 2007. © 2007 Wiley Periodicals, Inc.

Arguments for slavery reparations have fallen out of favor even as reparations for other forms of racial injustice are taken more seriously. This retreat is unsurprising, as arguments for slavery reparations often rely on two normatively irregular claims: that reparations are owed to the dead (as opposed to, say, their living heirs), and that the present generation inherits an as yet unrequited guilt from past generations. Outside of some strands of Black thought and activism on slavery reparations, these claims are (...) widely rejected. I develop an argument for slavery reparations around those foundational claims by adopting the normative framework of Immanuel Kant. On what I call the Basic Argument for slavery reparations, the application of Kant’s retributivist theory of punishment to slavery justifies reparations as a kind of proportional punishment for slavery. I also show that Kant’s philosophy offers reparations theorists resources to overcome several contemporary objections to slavery reparations. (shrink)

The primary impediment to formulating a general theory for adaptive evolution has been the unknown distribution of fitness effects for new beneficial mutations. By applying extreme value theory, Gillespie circumvented this issue in his mutational landscape model for the adaptation of DNA sequences, and Orr recently extended Gillespie's model, generating testable predictions regarding the course of adaptive evolution. Here we provide the first empirical examination of this model, using a single-stranded DNA bacteriophage related to phiX174, and find that our data (...) are consistent with Orr's predictions, provided that the model is adjusted to incorporate mutation bias. Orr's work suggests that there may be generalities in adaptive molecular evolution that transcend the biological details of a system, but we show that for the model to be useful as a predictive or inferential tool, some adjustments for the biology of the system will be necessary. (shrink)

The theory of evolution unites the past, present, and future of living things. It puts humanity's place in the universe into necessary perspective. Despite a history of controversy, the evidence for evolution continues to accumulate as a result of many separate strands of incredible scientific sleuthing. In The Story of Evolution in 25 Discoveries, Donald R. Prothero explores the most fascinating breakthroughs in piecing together the evidence for evolution. In twenty-five vignettes, he recounts the dramatic stories of the people who (...) made crucial discoveries, placing each moment in the context of what it represented for the progress of science. He tackles topics like what it means to see evolution in action and the distance between species in space and time, following figures from Darwin to lesser-known researchers as they unlock the mysteries of the fossil record, the earth, and the universe. The book also features the stories of animal species strange and familiar, including humans-and our ties to some of our closest relatives and more distant cousins. Prothero's wide-ranging tales showcase awe-inspiring and bizarre aspects of nature and the powerful insights they give us into the way that life works. (shrink)

The Republic represents the good life as some sort of harmony or composition between the different interests of which the threefold nature of the soul makes it capable. The rational factor, τ λολιστικν, not only chooses which impulses shall be satisfied and which rejected but is credited also with impulses of its own, such as the desire for knowledge, to the importance of which the Republic testifies by various strands of argument. But in Plato's attempt to prove the goodness of (...) this mixed life he may be thought to have relied too much on arguments about its pleasantness. If he had really meant from the first to prove against Thrasymachus that the just life is more prolific in pleasure1 than the unjust, he would have had to undertake the task of proving a necessary connection between just activities and pleasant states of feeling which could scarcely exist unless feelings were under the control of the will. If this had been his intention, the whole weight of the argument would rest on the two comparatively short passages in Book IX in which he makes first a dubious appeal to experience and then, by an equally dubious piece of metaphysics, attempts to reinforce his ethical conclusion by denying the reality of such pleasures as might tend to throw doubt on it. (shrink)

This is a series of two articles examining Kant’s attitude toward mystical experiences and the relation between his interest in these and his interest in constructing a Critical system of metaphysics.“The Critical Dreams” begins by questioning the traditional division between “Critical” (1770 onwards) and “pre-Critical” periods in Kant’s development. After explaining Kant’s Critical method, his 1766 book, Dreams of a Spirit-Seer... is examined and found to contain all the essential elements of that method. The onlykey element which is missing is (...) his “Copernican” insight. Although Hume may have played an important role in the early 1760’s in awakening Kant to the importance of his Critical method, this Copernican insight seems to have its roots more in Swedenborg than in Hume. Moreover, [DREAMS] itself should no longer be interpreted as evincing a sceptical or empirical stage in Kant’s development, but can now be seen as setting for Kant the problem which his Critical System was intended to solve. [DREAMS] suggests the two strands of this problem: (1) How is mystical experience possible? and (2) How is metaphysics possible? [DREAMS] offers a Critical answer to the first question, but does not fully develop its implications. (shrink)

An eminently readable essay in the history of ideas. Various strands of Primitive Christianity are identified against the backgrounds of their antecedents: the Old Testament heritage whose history of the world was the history of God's work; the legalistic ritualism of Judaism against which Jesus protested; the wedding of Judaism with Greek rationalism in Hellenistic Alexandria; and the philosophic schools of the Greek world.--R. G. S.

Until fairly recently a common way of doing history of science was to pick up an important strand of contemporary scientific thought and to trace its origin back to the philosophical tangle of the scientific revolution. This approach conveniently by-passed the breakdowns of once useful and pervasive theories, and neglected the long intellectual journeys along devious routes. History of science read like a success story; the pioneers who failed were neither dismissed nor excused; they were simply ignored. The historian (...) knew what he was hunting for and he was careful to limit his search to areas where his quarry was sure to be found. This method, which has been dubbed the precursor-view, stands in contrast—albeit, not in opposition—to the contextual method, which aims at a better understanding of the actual thought-processes of the early scientists. On this second view, history of science must not only account for present theories in the light of past developments, it must also assess old theories in terms of the scientist's conceptual framework, and judge them against the background of the world picture of his age. This may lead the historian down the blind alleys of the past, chasing spurious attempts at explaining the nature of physical reality, but it can clear the ground for a less anachronistic interpretation of the emergence of modern science and the actual process of discovery. History of science acts as a winnowing fork, but we cannot suppose that the discoverer himself always separated the wheat from the chaff, and we must be ever wary of equating the dream with the task. (shrink)

In this brief essay Vanhoutte treats the complex structure of the Gorgias with remarkable care. Freedom and constraint in human responses and in the form of discussion are the key strands he separates.--R. P.

Developed from the author's own explorations as a poet and novelist, from the classics of European existential philosophy, and from the "positive existentialism" of Nicola Abbagnano, this work presents a creative and careful integration of divergent strands in contemporary philosophy. Invrea contributes an original discussion of the complementary characteristics of subjective existence--"situationality" and temporality. This study displays the vigor and seriousness of the Italian existentialists.--R. C. D.

In this brief essay Vanhoutte treats the complex structure of the Gorgias with remarkable care. Freedom and constraint in human responses and in the form of discussion are the key strands he separates.--R. P.

The primary purpose of this book is to probe the "deep common sources" of Wittgenstein’s Investigations and Remarks on the Foundation of Mathematics in his later philosophy of language. The question is whether Wittgenstein’s thought about mathematics can be presented sympathetically, and so defended from charges of superficiality or eccentricity which have often been levelled against it. There are other strands in this complex, simultaneously gripping and maddening work, including confrontations of varying extent with relevant doctrines of Dummett, Davidson, and (...) Quine, to cite the main cases. The character of Wittgenstein’s own thought was far from systematic, yet this does not seem to justify the virtual lack of systematic presentation of his defense by Wright. We can, nevertheless, pick out the main thrust of Wright’s case. The author takes his bearings by the quarrel within twentieth century philosophy of mathematics between platonism and intuitionism. Platonism may be briefly described as the view that, if p is a mathematical proposition, we know what would be the case if p were true, even if we can't show that p is true. For intuitionism, on the other hand, to know what would be the case if p were true, is impossible unless we can show that p is indeed true. (shrink)

Long DNA palindromes pose a threat to genome stability. This instability is primarily mediated by slippage on the lagging strand of the replication fork between short directly repeated sequences close to the ends of the palindrome. The role of the palindrome is likely to be the juxtaposition of the directly repeated sequences by intrastrand base‐pairing. This intra‐strand base‐pairing, if present on both strands, results in a cruciform structure. In bacteria, cruciform structures have proved difficult to detect in vivo, (...) suggesting that if they form, they are either not replicated or are destroyed. SbcCD, a recently discovered exonuclease of Escherichia coli, is responsible for preventing the replication of long palindromes. These observations lead to the proposal that cells may have evolved a post‐replicative mechanism for the elimination and/or repair of large DNA secondary structures. (shrink)

DNA topoisomerases are enzymes that can modify, and may regulate, the topological state of DNA through concerted breaking and rejoining of the DNA strands. They have been believed to be directly involved in DNA excision repair, and perhaps to be required for the control of repair as well. The vicissitudes of this hypothesis provide a noteworthy example of the dangers of interpreting cellular phenomena without genetic information and vice versa.

This volume is a comprehensive roadmap to the burgeoning area of affective sciences, which now spans several disciplines. The Handbook brings together, for the first time, the various strands of inquiry and latest research in the scientific study of the relationship between the mechanisms of the brain and the psychology of mind. In recent years, scientists have made considerable advances in understanding how brain processes shape emotions and are changed by human emotion. Drawing on a wide range of neuroimaging techniques, (...) neuropsychological assessment, and clinical research, scientists are beginning to understand the biological mechanisms for emotions. As a result, researchers are gaining insight into such compelling questions as: How do people experience life emotionally? Why do people respond so differently to the same experiences? What can the face tell us about internal states? How does emotion in significant social relationships influence health? Are there basic emotions common to all humans? This volume brings together the most eminent scholars in the field to present, in sixty original chapters, the latest research and theories in the field. The book is divided into ten sections: Neuroscience; Autonomic Psychophysiology; Genetics and Development; Expression; Components of Emotion; Personality; Emotion and Social Processes; Adaptation, Culture, and Evolution; Emotion and Psychopathology; and Emotion and Health. This major new volume will be an invaluable resource for researchers that will define affective sciences for the next decade. (shrink)

There is a wide scholarly consensus that Nietzsche's GM contains two principal projects. First, GM aims to explain—historically and psychologically—how some of morality's central strands emerged and evolved into their contemporary forms; and, second, GM aims to provide a critical assessment of the value of morality itself. Brian Leiter captures this consensus when he writes, "By investigating the origin of morality Nietzsche hopes to undermine morality or, more precisely, to loosen the attachment of potentially great human beings to this morality."1 (...) But if the scholarly consensus is correct, the opening section of the preface to GM presents us with a puzzle. The opening passage bears no obvious... (shrink)

Open peer commentary on the article “Second-Order Cybernetics as a Fundamental Revolution in Science” by Stuart A. Umpleby. Upshot: Theory without a strong methodology is stranded in philosophy. Principles devolved from theory can be applied to situations in the arena of practice in many ways; however, a continually improving science must refine its theories with feedback from data drawn from the use of continually improving sets of codified methodologies. Second-order cybernetics is contingent upon sense-making within sapient systems. A perspective on (...) cognitive science points toward the requirements for an enabling sense-making methodology for second-order cybernetic science. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:95. HUME AND NONLOGI CAL NECESSITY Flew substantially agrees with our main themes in Causal Powers, though he thinks our discussion should begin closer to the work of Hume himself. What to reply? Needless to say, we find no fault in his agreement with us and are happy for his support. The answer to the second part of his response is far more complicated and requires a bit of (...) background from Causal Powers. While contemporary Humeans differ in important details, they share certain commitments which constitute what we call the Humean tradition. This tradition and contemporary refinements of it are the targets of our criticisms and provide the crucial foil for presenting our own positive theory of natural necessity. Two important strands of the tradition, as we characterized it, are the In-principle (No-contradiction) argument and the argument against the possibility of a priori knowledge of matters of fact. (i) Since nature may change its course, 'C and not E' is not self-inconsistent. To the Humean the phrase "change in the course of nature" seems intuitively clear; to us it seems utterly opaque and itself in great need of analysis. We show that there are two possible interpretations of the phrase, one of which is selfinconsistent while the other, though coherent, does not establish the Humean conclusion that there is no necessary connection between matters of fact, (ii) The Humean assumes that 'p is contingent' and 'p is a posteriori. ' and 'p is necessary' and 'p is a priori, ' are materially equivalent, and then argues easily that since all causal propositions are a posteriori none of them can be a priori and so necessary. We offer numerous arguments to break up the assumed equivalencies and thus defeat the conclusion 96. of the Humean argument. We show that while all scientific propositions are indeed known a posteriori it does not follow that there are no justifiable propositions about natural kinds. Philosophers in other traditions have made a similar point in showing that "metaphysical necessity" does not entail "epistemic necessity." Indeed, in contrast to many contemporary Humeans, we are complete fallibilists and even reject the notion that there is a self-contained given which is incorrigible. In portraying various strands of "the Humean tradition" in Causal Powers, we were, of course, imputing these views to Hume himself. How could it be otherwise? In referring to the Humean tradition instead of to Hume we meant only to indicate (as do contemporary Humeans) that we were concerned only with what we take to be still very much alive in Hume's work. Hence it is puzzling to read Flew' s remark that we relate our own contributions to Hume "only most distantly." That we and contemporary Humeans are always correct in what we ascribe to Hume and in what we take to be still philosophically alive in his work may be open to question, but since Flew does not challenge any specific ascription there is no alleged misinterpretation to defend ourselves against. Flew suggests that we should show Hume to be wrong at the outset — convict him, so to speak, on the grounds of the inconsistencies in his own texts. He refers to the famous definition of 'cause' in the Inquiry, where Hume gives a factual rendition of 'cause' and then innocently equates it with a counterfactual counterpart. C. J. Ducasse, for many years an ardent critic of Hume texts, made this point nicely in 1924 in his splendid book Causation and the Types of Necessity. After quoting Hume's definition in the Inquiry Ducasse remarked: This statement, incidentally, is immediately followed by: "Or in other words where, if the first object had not been, the second never had 97. existed." But this, far from being only a different way of saying precisely the same thing, is on the contrary a precise way of saying a very different thing. For Hume very definitely maintains elsewhere that there is never any "if-ness" objectively observable at all, but only a "that-ness" constantly repeated in experience. So that only the first statement is consistent with his empiricism, and even in that first statement the words "are followed" should in strictness be replaced by... (shrink)

Approximately 1,500 years ago John Philoponus proposed a simple argument for the existence of God. The argument runs thus: Whatever comes to be has a cause of its coming to be. The universe came to be. Therefore, the universe has a cause of its coming to be. ;Due to the influence of William Lane Craig, this argument and the family of arguments that support it have come to be known as the "kalam" cosmological argument . Craig's account of the KCA (...) incorporates features that serve to distinguish his version as a significant advance. First, conceptual advances in mathematics now permit a clearer presentation of the argument than was previously possible. Second, contemporary Big Bang cosmology confirms the central contention of the KCA, namely, that the past existence of the universe is finite. Reflection upon the implications of using Cantorian transfinite mathematics to model physical processes allowed Craig to develop a distinctively philosophical version of the KCA which is relatively independent of changes in contemporary scientific cosmology. This dissertation is intended as a critical investigation and development of this philosophical strand of the KCA. The literature relating to the KCA has grown however to a significant bulk, and there is now danger of duplication and misassessment due to the plurality of interpretations that the argument has received. Part I of the dissertation addresses this need by laying bare the underlying logical structure of the KCA and by providing a comprehensive "state of the question" . Part II of the dissertation, comprising chapters 3 through 6, focuses upon an important species of objection made to the KCA. This species of objection relies upon thought-experiments designed to show that an actual infinity is possible. I reply: this objection is effectively answered by introducing a metaphysics of substances. In the course of presenting a systematic response I develop an interpretation of the notion of substance that is useful for analytic philosophy, present a general account of the logical requirements of KCA thought-experiments, and outline a theory of logical modality suited to the metaphysical requirements of the KCA. (shrink)

In this article, we reflect on our lived experience as co-facilitators of a promising intragroup anti-racism process within the Dutch Reformed Church (DRC) in South Africa. Firstly, we describe how this emergent process, referred to as ‘white work’, has developed since 2018 to include three focal areas: facilitation and training, research and the development of resources for faith leaders. Secondly, in the interest of localised, embodied diagnostic work, we mention relatively neglected strands of South African whiteness that have arisen through (...) this process of ‘white work’. We argue that this DRC ‘white work’ contributes to a more intersectional approach to dismantling whiteness. Finally, we propose that the dismantling potential of this ‘white work’ rests on three dimensions – raising consciousness, cultivating capacity and forming community – while stressing some of the challenges and limitations we have encountered in our process thus far.Contribution: This article contributes to both the diagnosis and dismantling of South African whiteness by presenting a narrative reflection on an emergent process among members of the DRC in South Africa. (shrink)

An eminently readable essay in the history of ideas. Various strands of Primitive Christianity are identified against the backgrounds of their antecedents: the Old Testament heritage whose history of the world was the history of God's work; the legalistic ritualism of Judaism against which Jesus protested; the wedding of Judaism with Greek rationalism in Hellenistic Alexandria; and the philosophic schools of the Greek world.--R. G. S.